Dr. Gabriel Herrero-Beaumont Cuenca

• Director del Laboratorio de Investigación de Patología Osteoarticular.
• Encargado de la asignatura de Reumatología en la Facultad de Medicina de la UAM. Profesor titular de Reumatología

Desde 1982 hasta 2011: 124 publicaciones

En 2012-2013 ha realizado otras 21 publicaciones:

• Andrés-Bergós J, Tardio L, Larranaga-Vera A, Gómez R, Herrero-Beaumont G, Largo R. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012 Sep 28;287(40):33615-28. Epub 2012 Aug 2. PubMed PMID: 22859309; PubMed Central PMCID: PMC3460460.
• Lugo L, Villalvilla A, Gómez R, Bellido M, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G, Roman-Blas JA. Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis. Osteoarthritis Cartilage. 2012 Dec;20(12):1619-30. doi: 10.1016/j.joca.2012.08.010. Epub 2012 Aug 27. PubMed PMID: 22935787
• Martínez-Calatrava MJ, Prieto-Potín I, Roman-Blas JA, Tardio L, Largo R, Herrero-Beaumont G. RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis. Arthritis Res Ther. 2012 Jun 18;14(3):R149. doi: 10.1186/ar3884. PubMed PMID: 22709525; PubMed Central PMCID: PMC3446534.
• Almagro MI, Roman-Blas JA, Bellido M, Castañeda S, Cortez R, Herrero-Beaumont G. PTH [1-34] enhances bone response around titanium implants in a rabbit model of osteoporosis. Clin Oral Implants Res. 2012 May 25. doi: 10.1111/j.1600-0501.2012.02495.x. [Epub ahead of print] PubMed PMID: 22626278.
• Castañeda S, Martínez Calatrava MJ, Herrero-Beaumont G. [Alternatives in the treatment of rheumatoid arthritis: reasons for using abatacept]. Rev Clin Esp. 2012 May;212(5):244-54. doi: 10.1016/j.rce.2011.09.008. Epub 2011 Dec 15. Review. Spanish. PubMed PMID: 22176928.
• Herrero-Beaumont G, Martínez Calatrava MJ, Castañeda S. Abatacept mechanism of action: concordance with its clinical profile. Reumatol Clin. 2012 mar-Apr;8(2):78-83. doi: 10.1016/j.reuma.2011.08.002. Epub 2011 Nov 21. Review. PubMed PMID: 22104048.
• Castañeda S, Roman-Blas JA, Largo R, Herrero-Beaumont G. Subchondral bone as a key target for osteoarthritis treatment. Biochem Pharmacol. 2012 Feb 1;83(3):315-23. doi: 10.1016/j.bcp.2011.09.018. Epub 2011 Sep 22. Review. PubMed PMID: 21964345.
• Sanchez-Pernaute O, Filkova M, Gabucio A, Klein M, Maciejewska-Rodrigues H, Ospelt C, Brentano F, Michel BA, Gay RE, Herrero-Beaumont G, Gay S, Neidhart M, Juengel A. Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts Ann Rheum Dis published 12 December 2012, 10.1136/annrheumdis-2012-201906
• Pérez Esteban S, Herrero-Beaumont G. Osteoimmunology, osteorheumatology or rheumatology alone? Reumatol Clin. 2013 May 2. doi:pii: S1699-258X(13)00061-2. 10.1016/j.reuma.2013.03.002. PMID: 23643640
• Acebes C, Romero FI, Contreras MA, Mahillo I, Herrero-Beaumont G. Dynamic ultrasound assessment of medial meniscal subluxation in knee osteoarthritis. Rheumatology (Oxford). 2013 Apr 16. [Epub ahead of print] PMID:23594469
• Castañeda S, Roman-Blas JA, Cohen-Solal M, Largo R, Herrero-Beaumont G. Is lecturing in Rheumatology Satellite Symposia a male attribute? Rheumatol Int. 2013 Apr 16. [Epub ahead of print] PMID: 23588408
• Henrotin Y, Chevalier X, Herrero-Beaumont G, McAlindon T, Mobasheri A, Pavelka K, Schön C, Weinans H, Biesalski H; Participants at the Hohenheim Consensus Conference in August 29th 2011.Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. BMC Res Notes. 2013 Mar 26;6:115. doi: 10.1186/1756-0500-6-115. PMID: 23531101
• Navarro-Sarabia F, Herrero-Beaumont G. Viscosupplementation for osteoarthritis of the knee. Ann Intern Med. 2013 Jan 1;158(1):74-5. doi: 10.7326/0003-4819-158-1-201301010-00019. PMID: 23277908
• Gómez R, Villalvilla A, Largo R, Gualillo O, Herrero-Beaumont G. LCN2 a new catabolic adipokine produced by human osteoblasts. Submitting for publication. Annals of the Rheumatic Diseases. A. IF: 8.727
• Gómez R, Villalvilla A, Largo R, Gualillo O, Herrero-Beaumont G. LCN2 a new adipokine involved in bone and cartilage crosstalk. 2013. Submitting for publication. Arthritis and Rheumatism. A. IF:7.866.
• Villalvilla A, da Silva JA , Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R: 6-Shogaol inhibits chondrocytes’ innate immune responses and cathepsin-K activity. Molecular Nutrition and Food Research. 2013. Under second revision. A. IF: 4.301
• Prieto-Potín I, Roman-Blas JA, Martínez-Calatrava MJ, Gómez R, Largo R, Herrero-Beaumont G. Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration. Arthritis Research Therapy. En prensa.
• Castañeda S, Roman-Blas J, Largo R, Herrero-Beaumont G. Osteoarthritis is a progressive disease with changing phenotypes. Rheumatology. En prensa.
• Vicente E, Herrero-Beaumont G, Castañeda S. Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Review of Clinical Immunology. En prensa.
• Roman-Blas JA, Castañeda S, Largo R, Lems W, Herrero-Beaumont G. An OA phenotype(s) may obtain major benefit from bone acting agents. Sem Arthritis Rheum. Under first revision.
• Herrero-Beaumont G, Roman-Blas J. Osteoporotic OA: a reasonable target for bone acting agents. Nature Review Rheumatology. En prensa.

Desde 1985 hasta 2011: 140 comunicaciones

En 2012-2013:

• Martínez-Calatrava MJ, Prieto-Potín I, Roman-Blas J, Tardio L, Largo R, Herrero-Beaumont G. Rankl produced by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis. 32st European Workshop for Rheumatology Research (EWRR) Workshop. Ann Rheum Dis 2012;71(Suppl1): A68.
• Villalvilla A, Almada J, Vieira PC, Largo R, Herrero-Beaumont G, Gómez R. Shogaol inhibits cathepsin-K activity and has anti-catabolic and anti-inflammatory properties in stimulated chondrocytes. 32st European Workshop for Rheumatology Research (EWRR) Workshop. Ann Rheum Dis 2012;71(Suppl1): A68.
• Andrés-Bergós J, Tardío L, Villalvilla A, Gómez R, Herrero-Beaumont G, Largo R. O-GLCNAC protein modification stimulates chondrogenesis in vitro and chondrocyte hypertrophy in mouse. 32st European Workshop for Rheumatology Research (EWRR) Workshop. Ann Rheum Dis 2012;71(Suppl1): A71.
• Subchondral bone remodelling and osteoarthritis. Román-Blas J, Castañeda S, Largo R, Herrero-Beaumont G. Proceedings of Osteorheumatology 2011: International Congress on Bone Involvement in Arthritis. Santa Margherita Ligure, Italy. 13-14 October 2011. Arthritis Research & Therapy 2012, 14(Suppl 2):A6.
• Prieto-Potin, M. J. Martínez-Calatrava, J. A. Román-Blas, R. Largo, L. Tardío, G. Herrero-Beaumont. Rankl produced by articular chondrocytes induces bone loss associated with arthropathies. Osteoathritis Cartilage 2012; 20: S65.
• Herrero-Beaumont G, Tardío L, Gómez-Barrena E, Andrés J, Largo R. Identification of an extracelular O-N-acetyl-glycosylase responsable forn an increased level of O-linked N-acetylglucosamine modified proteins in the cartilage of patients with osteoarthritis. Osteoathritis Cartilage 2012; 20: S6118.
• Largo R, Tardío L, Andrés J, Herrero-Beaumont G. Study of the O-N-GlucNac of proteins induced by high doses of glucosamine and its correlation with osteroarthritis progression. Osteoathritis Cartilage 2012; 20: S6126.
• Lugo, L, Villalvilla A, Gómez R, Largo R, Herrero-Beaumont G. Functional estrogen biosynthesis machinery is expressed in human postmenopausic osteoarthritis chondrocytes. Osteoathritis Cartilage 2012; 20: S141.
• Andrés J, Tardío L, Villalvilla A, Gómez-Barrena E, Herrero-Beaumont G, Largo R. O-N-GlcNac protein modification stimulates chondrogenesis in vitro and chondrocyte hypertrophy in mouse. Osteoathritis Cartilage 2012; 20: S6150.
• Navarro F, Toyos J, Herrero-Beaumont G, Coronel P, Gimeno M, Hernández Cruz B. Knee joint space width progression: Results of a 3,3 years randomized, doublé blind clinical trial with hyaluronic acid. Osteoathritis Cartilage 2012; 20: S6168.
• Perez-Ferro M, Recuero S, Romero F, Serrano C, Rodriguez-Nieto M, Gomez-Seco J, Presa T, Godo J, Gabriel Herrero-Beaumont G, Sanchez-Pernaute O. Effect of Repeated Infusions of Rituximab in Patients with Primary Sjögren’s Syndrome. Arthritis Rheum 2012; 64: S749-S750.
• Prieto-Potin I, Martínez-Calatrava MJ, Román-Blas JA, Tardio L, et al. Does RANKL produced by articular chondrocytes actively participate in juxta-articular bone loss related to chronic arthritis? Bone 2012; 50: S97.
• Tardio L, Andrés-Bergós J, Herrero-Beaumont G, Largo R. Study of the O-linked-N-acetyl-glucosaminylation of proteins induced by high doses of glucosamine and its correlation with osteoarthritis progression. Bone 2012; 50: S99.
• Villalvilla A, Gómez R, Largo R, Herrero-Beaumont G, et al. Human articular chondrocytes from elderly osteoarthritic woman synthesize local estradiol through steroidogenesis reactions catalyzed by aromatase and 17beta-hydroxysteroid dehydrogenase. Bone 2012; 50: S95.
• Villalvilla A, Silva JA, Cezar P, Largo R, Herrero-Beaumont G. Anti-inflammatory and anti-resoptive properties of ginger derivatives. Bone 2012; 50: S99.
• Andrés-Bergós J, Tardío L, Villalvilla A, Gómez R, Largo R, Herrero-Beaumont G. O-GlcNAc protein modification stimulates chondrogenesis in vitro and chondrocyte hypertrophy in mouse. Bone, 2012 Bone; 50: S119.
• Ferreiro-Iglesias A, Calaza M, Perez-Pampin E, Lopez-Longo FJ, Marenco JL, Blanco F, Narvaez J, Navarro F, Cañete JD, Herrero-Beaumont G, et al. Genomics, genetic basis of disease and replication of interactions between polymorphisms in rheumatoid arthritis susceptibility. Ann Rheum Dis 2013; 72(Suppl3): 165
• Castañeda S, Guede D, Caeiro JR, Roman-Blas J, Largo R, Herrero-Beaumont G. Transitional zones displacement of the subchondral bone layers in a model of osteoporosis and osteoarthritis in rabbits. Ann Rheum Dis 2013; 72(Suppl3): 381
• Loricera J, Blanco R, Castañeda S, Umbría A, Melchor S, Rubio R, Calvo-Alen J, Aurrecoechea E, Rúa-Figueroa I, Ortego N, Minguez M, Herrero-Beaumont G et al. Biologic therapy in aortitis: a multicenter study of 30 patients. Ann Rheum Dis 2013; 72(Suppl3): 030