The laboratory of Immunology at the Hospital Quirón Torrevieja is focused on both the diagnosis of different types of pathologies and the treatment of oncological patients.
Our clinical activity includes the diagnosis and follow-up of hematological neoplasms by means of cytometric analysis, the treatment of oncological patients by adoptive immunotherapy and the assessment of the immune functional response. We also have special programs for the treatment of cancer patients.
Flow cytometry techniques (diagnostic)
The objective of this group of techniques is the characterization of the different lymphocyte subpopulations present in the patient's blood as indicators of the immunological status, or the identification of aberrant populations resulting from a hematological pathology equally in blood, bone marrow, lymph node or other biological samples. In our portfolio of services, the diagnosis of hematological malignancies stands out through screening tests and phenotypic characterization, and the monitoring of these pathologies through monitoring tests and minimal residual disease studies.
Adoptive immunotherapy (therapeutic)
The aim of adoptive immunotherapy treatments is to achieve a specific immune response against tumor tissue. There are different types of treatments, depending on the availability of the sample. Currently, techniques for the culture of TIL cells (tumor infiltrating lymphocytes), CTL cells (cytotoxic T lymphocytes), LAK cells (cytotoxic cells activated by lymphokines), CIK cells (cytokine cells induced by cytokines) and dendritic cells are developed.
Immune functional response
There are several determinations that allow the functional characterization of the immune response in oncological patients receiving an immunotherapeutic treatment:
- Study of soluble cytokines in serum (IL-2, IL-6, TNF-β, VEGF).
- In vitro study of cytokine production (IFN-gamma) by tumor-specific lymphocytes (ELISPOT).
- Study of the in vitro proliferative response of tumor-specific lymphocytes.
- Study of anti-tumor peptide antibodies in serum.
The laboratory of Immunology of the Hospital Quirón Torrevieja is integrated into a multidisciplinary platform for the diagnosis and treatment of cancer patients. Therefore, the special programs developed focus primarily on these two areas. Immunotherapeutic treatments are administered as complementary treatments to other conventional therapies in oncological patients, so it is in the multidisciplinary environment where the patients are indicated and when they are integrated into the immunotherapy program, as well as the time of administration. These advanced therapy medications are elaborated in the Cell Production Units or White Rooms complying with the current legislation.
Among these special programs is the manufacture of vaccines with autologous dendritic cells pulsed with tumor peptides for the treatment of patients with prostate cancer.